使用計(jì)算機(jī)控制的刺激量化機(jī)械敏感性

評(píng)估超閾值機(jī)械敏感性

測(cè)量機(jī)械閾值而不進(jìn)行多次測(cè)試

范圍：0.5N - 10N

卓越的分辨率（至0.3mN）

以任何方向運(yùn)作

***小化軸外力

提供的提示范圍（0.5,0.8,1,1.5,2,3毫米直徑）

應(yīng)用區(qū)域在整個(gè)力范圍內(nèi)保持不變

參考文獻(xiàn)：

Kumar, Siddarth. et al. “Viscoelastic characterization of the primate finger pad in vivo by microstep indentation and three-dimensional finite element models for tactile sensation studies .” Journal of Biomechanical Engineering 137.6 (2015): 061002.

Qi, Huixin et al. “Cortical neuron response properties are related to lesion extent and behavioral recovery after sensory loss from spinal cord injury in monkeys.” The Journal of Neuroscience 34.12 (2014): 4345-4363.

Dieudonné, Alexandre et al. “Encoding properties of the mechanosensory neurons in the Johnston's organ of the hawk moth, Manduca sexta.” The Journal of Experimental Biology 217.17 (2014): 3045-3056.

Milenkovic, Nevena et al. “A somatosensory circuit for cooling perception in mice.” Nature Neuroscience17.11 (2014): 1560-1566.

Reed, Jamie L. et al. “Effects of spatiotemporal stimulus properties on spike timing correlations in owl monkey primary somatosensory cortex.” Journal of Neurophysiology 108.12 (2012): 3353-3369.

Jankowski, Michael P. et al. “Dynamic changes in heat transducing channel TRPV1 expression regulate mechanically insensitive, heat sensitive C-fiber recruitment after axotomy and regeneration.” The Journal of Neuroscience 32.49 (2012): 17869-17873.

Molliver, Derek C. et al. “The ADP receptor P2Y1 is necessary for normal thermal sensitivity in cutaneous polymodal nociceptors.” Molecular Pain 7.1 (2011): 13.

Ge, Weiqing, and Partap S. Khalsa. “Encoding of compressive stress during indentation by group III and IV muscle mechano-nociceptors in rat gracilis muscle.” Journal of Neurophysiology 89.2 (2003): 785-792.

Bove, Geoffrey M., Daniel R. Robichaud, and Peter Grigg. “Three-dimensional load analysis of indentation stimulators.” Journal of Neuroscience Methods 123.1 (2003): 23-30.

Khalsa, Partap S., Ce Zhang, and Yi-Xian Qin. “Encoding of location and intensity of noxious indentation into rat skin by spatial populations of cutaneous mechano-nociceptors.” Journal of Neurophysiology 83.5 (2000): 3049-3061.

300C-I機(jī)械刺激器是***種自動(dòng)電子von Frey設(shè)備，具有在單個(gè)應(yīng)用點(diǎn)測(cè)量和控制力和長(zhǎng)度的附加功能。300C-I采用手持式von Frey燈絲或其他手持式機(jī)械刺激器來(lái)消除力量的變化和尷尬。我們的計(jì)算機(jī)控制機(jī)械刺激器消除了與von Frey細(xì)絲和其他電子von Frey系統(tǒng)相關(guān)的不可避免的手震顫。這消除了力應(yīng)用中的相關(guān)變化。

Aurora Scientific的機(jī)械刺激器無(wú)需多次測(cè)試即可確定閾值，從而提高了吞吐量。力的施加和刺激的時(shí)間是***致和精確的，從而消除了與手持設(shè)備相關(guān)的可變性。

機(jī)械刺激器能夠在預(yù)設(shè)的時(shí)間段內(nèi)施加恒定的力，并具有以預(yù)定速率調(diào)節(jié)力的附加功能。刺激可以以長(zhǎng)度或力的任何組合應(yīng)用，并且可以遵循任意的力或距離施加曲線，因此施力不限于簡(jiǎn)單的力斜坡。

恒定和可重復(fù)力的傳遞確保實(shí)驗(yàn)，受試者和研究之間保持***致性，從而減少數(shù)據(jù)中可避免的錯(cuò)誤并提高您的發(fā)現(xiàn)質(zhì)量。